diff --git a/README.rst b/README.rst
index f0a6954ca2626dfceb5ce1d9a32004f121711243..f781a0607d967313139e64fd7d2c827bf3beba1a 100644
--- a/README.rst
+++ b/README.rst
@@ -12,23 +12,25 @@ that node.
 
 (optionally) Set up the environment::
 
-   source setup_env.sh
-
-On Maxwell execution rights might be stripped. If you get
-an error for the above command, first run::
-
-   chmod +x setup_env.sh
-
-If running headless, be sure to set `MPLBACKEND=Agg`, via::
+   module load python3
+   pip install --user ipython --upgrade
+   pip install --user ipyparallel --upgrade
+   pip install --user dill
+   
+If running headless (i.e. without X forwarding), be sure to set 
+`MPLBACKEND=Agg`, via::
 
    export MPLBACKEND=Agg
 
-This is automatically done if you source the environment script.
+Then start an `ipcluster`. If you followed the steps above this can be done
+via::
+
+   ~/.local/bin/ipcluster start --n=32
 
 
 Run the script::
 
-    python calibrate.py --input /gpfs/exfel/exp/SPB/201701/p002012/raw/r0100 \
+    python3 calibrate.py --input /gpfs/exfel/exp/SPB/201701/p002012/raw/r0100 \
        --output ../../test_out --mem-cells 30 --detector AGIPD --sequences 0,1   
 
 Here `--input` should point to a directory of `RAW` files for the detector you
@@ -39,6 +41,10 @@ for the run, as well as the `--detector`. Finally, you can optionally
 specify to only process certain `--sequences` of files, matching the sequence
 numbers of the `RAW` input. These should be given as a comma-separated list.
 
+Finally, there is a `--no-relgain` option, which disables relative gain 
+correction. This can be useful while we still further characterize the detectors
+to provid accurate relative gain correction constants.
+
 You'll get a series of plots in the output directory as well.